Tryptase Level. It is necessary because there are some individuals who have an allergic reaction that causes a. The rise in tryptase levels starts to be detected in serum within minutes of anaphylaxis but the level will gradually revert to normal over the next 624 hours depending on the height of the increase and often correlates with the severity of the anaphylaxis.
Total serum tryptase concentrations in healthy nondiseased individuals range from 1 to 10 ngmL average 5 ngmL. Serum Tryptase is a marker of mast cell degranulation. An elevated tryptase does not distinguish between anaphylaxis and anaphylactoid reactions.
Tryptase EC 342159 is the most abundant secretory granule-derived serine proteinase contained in mast cells and has been used as a marker for mast cell activation.
In multivariate analysis the extent of urticaria was the best single predictor of plasma histamine levels and of either an elevated histamine or tryptase level. High serum tryptase levels are also one of the risk factors for adverse reaction in venom immunotherapy yet occasional patients are seen with raised levels in the absence of either diagnosis. Tryptase levels averaged SE 15962 ng per milliliter and histamine levels averaged 2605 ng per milliliter. A persistent large increase 20 ngml roughly double the upper limit of normal is more commonly associated with mastocytosis a rare disease featuring chronic inappropriate mast cell activation and a chronic cancerous.